Colonic delivery of α-linolenic acid by an advanced nutrient delivery system prolongs glucagon-like peptide-1 secretion and inhibits food intake in mice

Mol Nutr Food Res. 2021 Dec 9:e2100978. doi: 10.1002/mnfr.202100978. Online ahead of print.


SCOPE: Nutrients stimulate the secretion of glucagon-like peptide-1 (GLP-1), an incretin hormone, secreted from enteroendocrine L-cells which decrease food intake. Thus, GLP-1 analogs are approved for the treatment of obesity yet cost and side effects limit their use. L-cells are mainly localized in the distal ileum and colon, which hinders the utilization of nutrients targeting GLP-1 secretion. We propose a controlled delivery system for nutrients, inducing a prolonged endogenous GLP-1 release which results in a decreased food intake.

METHODS AND RESULTS: α-Linolenic acid (αLA) was loaded into thermally hydrocarbonized porous silicon (THCPSi) particles. In vitro characterization, and in vivo effects of αLA loaded particles on GLP-1 secretion and food intake were studied in mice. A total of 40.4 ± 3.2% of loaded αLA was released from particles into biorelevant buffer over 24 h, and αLA loaded THCPSi significantly increased in vitro GLP-1 secretion. Single-dose orally given αLA loaded mesoporous particles increased plasma active GLP-1 levels at 3 and 4 h and significantly reduced the area under the curve of 24 h food intake in mice.

CONCLUSIONS: αLA loaded THCPSi particles could be used to endogenously stimulate sustained gastrointestinal hormone release and reduce food intake. This article is protected by copyright. All rights reserved.

PMID:34882959 | DOI:10.1002/mnfr.202100978

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